PreforPro is unlike other prebiotic ingredients that require large doses and several days to begin working.~ John Deaton, Ph.D.

Understanding Prebiotics and Probiotics

Probiotics and Prebiotics Defined
The Food and Drug Administration (FDA) defines prebiotics as “a non-digestible food ingredient that beneficially affects the host by selectively stimulating the growth and/or activity of one or a limited number of bacteria in the colon, and thus improves host health.”1 The FDA defines a probiotic as “a living microorganism which, when administered in adequate amounts, confer health benefits to the host.”2 These microorganisms are usually bacteria and are sometimes referred to as “healthy”, “friendly”, “good” or “beneficial” bacteria. Probiotics are microorganisms similar to those that naturally exist in the gut3 . The idea is that in order to stay healthy, we must maintain a delicate balance of microflora (i.e. a mix of different bacteria) in the gastrointestinal tract. That balance can easily be upset if unwanted bacterial populations become predominant in the GI tract.

Balancing Bacterial Flora
A proliferation of harmful bacteria in the gut can rob your body of the essential nutrients it needs by consuming those nutrients that your body would normally absorb. Symptoms of unbalanced bacterial flora include4 :

  • Abdominal Pain
  • Indigestion
  • Bloating
  • Food Allergies
  • Malnutrition

In many cases, good bacteria have a difficult time displacing the unwanted bacteria and require help; this is where prebiotics come into play5 .

Prebiotics: Benefits and Drawbacks
Prebiotics are generally fibers or starches (e.g., oligosaccharides) that have been shown to be beneficial; however these can have some drawbacks6 , including:

  • They require large doses to be effective.
  • They can cause flatulence.
  • They are sensitive to their specific environment.
  • They only work in the colon.

References
1.Gibson, G.R. and Roberfroid, M.B., “Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics,” Journal of Nutrition, 125: 1401-1412 (1995).

2. Fuller, R., “Probiotics in Man and Animals,” Journal of Applied Bacteriology, 66: 365-378 (1989)

3. Food and Agriculture Organization and World Health Organization, “Health and Nutritional Properties of Probiotics in Food including Powder Milk with Live Lactic Acid Bacteria” (1-4 October 2001).

4. Elphick HL, Elphick DA, Sanders DS. Small bowel bacterial overgrowth. An underrecognized cause of malnutrition in older adults. Geriatrics. 2006 Sep;61(9):21-6.

5. Handbook of Prebiotics and Probiotics Ingredients, CRC Press, Boca Raton, FL 2009.

6. Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr. 2001 Feb;73(2 Suppl):415S-420S.

About PreforPro

As a result of extensive research, the scientists at Deerland Enzymes have developed a novel prebiotic that supports the growth of healthy bacteria in the gut through a mechanism that is not fiber or starch-based. PreforPro addresses the drawbacks of typical prebiotics on the market; benefits include:

EFFICACIOUS IN SMALL DOSES
within hours (not days).
FUNCTIONS IN BOTH
the small and large intestines.
DOES NOT CAUSE FLATULENCE
NOT AFFECTED
by varying gut environments.
WORKS WITH A BROAD SPECTRUM
of probiotic species.
PFP bottle
Supplemental Facts panels for Deerland Products.xlsx

 

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. The information contained in this website is intended for educational purposes only. If you are currently taking medications, or have other health-related conditions, consult a physician before adding supplements to your diet.

The Science

PreforPro has been shown under both physiological conditions in vitro and in vivo to preferentially promote the growth of beneficial Lactobacillus, Bifidobacterium and Bacillus subtilis strains when competing with undesirable bacterial strains. The effects are achieved at small doses within hours, in both the small and large intestine.

B longum

 

 

The accelerated growth of beneficial bacteria Bifidobacterium longum over the undesirable bacteria E.coli under physiological conditions

 

 

L lactis

 

 

The accelerated growth of beneficial bacteria Lactobacillus lactis under physiological conditions

 

 

Inulin
Bifidobacterium longum colony counts when competing against E. coli with the prebiotic Inulin compared to PreforPro. PreforPro provides a significant growth advantage for B. longum over inulin.

 

 

In-vivo growth of beneficial bacteria, B. longum, when competing with undesirable bacteria, E. coli, in different sections of the gastrointestinal tract of mice that were administered PreforPro.
in vivo

Frequently Asked Questions

What is PreforPro?
PreforPro is a novel prebiotic that supports the growth of healthy bacteria in the gut through a mechanism that is not fiber or starch‐based. Benefits include: 1) it is efficacious in small doses (15mg) within hours (not days), 2) it functions in both the small and large intestines, 3) it does not cause flatulence, 4) is not affected by varying gut environments, 5) it works with a broad spectrum of probiotic species.

How does it work?
PreforPro destabilizes the cell wall of bad bacteria, resulting in release of nutrients into the environment which can then be utilized by probiotics and the good bacteria of the GI tract. Because of the novel nature of the product and its patent-pending status, a Non-Disclosure Agreement must be signed in order to receive full details regarding the mechanism of action. Contact Deerland Enzymes for information.

Which probiotic strains were tested with PreforPro?
The bacteria below showed significant growth compared to the control while competing with bad bacteria.
• B. bifidum
• B. breve
• B. animalis
• B. longum
• L. acidophilus
• L. paracasei
• L. casei
• L. rhamnosus
• Lc. lactis
• B. subtilis

Is it Vegetarian or Vegan?
The formula is vegetarian and vegan in accordance with the guidelines of the American Vegetarian Association.

Is it non-GMO?
Yes, it is a non-GMO ingredient.

What is the recommended dosage?
Dosage: Take one 15mg capsule daily, or along with a probiotic.

Is it GRAS?
Yes, PreforPro is Generally Recognized as Safe (GRAS) by the FDA.

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