Go Glutalytic®: Enzymes Clinically Shown to Lessen Impact of Gluten

Wheat, rye and barley are certainly considered healthy foods, as they are low glycemic and contain beneficial vitamins and minerals- but for about 18 million Americans, these seemingly innocent grains unleash a boogeyman – gluten, a protein that is highly prominent in them. When an individual with gluten sensitivity or intolerance ingests gluten, it causes his/her immune system to act up in the small intestine, barring the absorption of key nutrients. Some of the complaints of discomfort after eating wheat or other gluten-containing foods are mostly GI-related, such as bloating, constipation, cramping and diarrhea. Others include head fog, low mood, and lack of energy.

A team of researchers led by Dr. Martin Hudson and Colin King at the Kennesaw State University Department of Biology found that a proprietary enzyme supplement reduced the intensity of symptoms caused by gluten ingestion. In the 2014 double-blind, randomized, placebo-controlled study, entitled, “Glutalytic® Clinical Trial for Normal Consumption of Gluten Containing Foods,” the researchers sought to clarify if the enzyme supplement had any impact on the reduction of symptoms from gluten consumption in those who were gluten intolerant.

At commencement of the four-week study, the participants had the highest frequency of symptoms. When Glutalytic was consumed as a supplement, the participants exhibited the least number of symptoms. The frequency, and severity of all symptoms were reduced when Glutalytic was administered. The data showed a statistically significant improvement when compared to the placebo group in the following categories: pain, bloating, emptying of bowels, hunger pains, stomach “rumbling,” lower energy levels, headaches, and food cravings.

In a second study in October of 2015, entitled, “Tolerance and Efficacy of Glutalytic®: A Randomized, Double-Blind, Placebo-Controlled Study”, 37 adults took either placebo or three capsules of Glutalytic daily for 30 days. The researchers used a comprehensive metabolic panel to evaluate C-reactive protein and gliadin antibody (igG, igA, EIA) levels and GI symptoms for tolerance and efficacy of the supplement.

Researchers found that at the end of the study, there were statistically significant decreases in IgA, an antibody that shows an immune response, and CRP, an indicator of inflammation levels. Further, the Glutalytic group also reported significant declines in several symptoms, most dramatically, GI reflux. And, interestingly, the supplement group also reported a reduction of cravings. This may be because when gluten is inhibited in the small intestine, more nutrients are absorbed and the body is sufficiently sated.

Collectively these study results are encouraging, especially for those consumers who do have gluten intolerance or gluten insensitivity, as well as for those who feel they may occasionally experience gluten-induced discomforts. Glutalytic has exceptional merit for those who cannot tolerate gluten. Because this protein is so prevalent, those who are highly sensitive may have symptoms just from cross-contamination in a commercial kitchen. And although more and more restaurants are offering gluten-free foods, gluten-free is not as ubiquitous as a sufferer would like, and therefore supplements featuring Glutalytic can provide peace of mind and much more confidence in eating.

The Problem with Dairy: Lactose Intolerance or Protein Sensitivity?

Dairy is a staple of American diets. It’s hard to resist cheese covered pizzas and pastas, or look the other way when presented with ice cream, custards, and cheesecakes. But as we grow older, our bodies seem to adversely react to dairy foods and beverages. There are two reasons for this: one, milk is biologically designed for children; and two, cow’s milk is, by nature, intended for baby cows. Still, a little digestive discomfort isn’t enough to stop us from partaking in delicious milk-based products. Besides, that’s what lactase enzyme supplements are made for. However, many people who pop these supplements and consume dairy can still experience bloating, nausea, cramps, upset stomach, gas, and diarrhea. In this case, the real culprit may not be lactose intolerance, but an immune response from the protein components of dairy.

But what is lactose intolerance exactly? Lactose is a large carbohydrate that requires the enzyme lactase in order to be broken down into simple sugars that can be absorbed by the body. As we transition into adulthood, the gene that produces lactase switches off, making it difficult for us to digest dairy.[1] This condition is common, and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) estimates that 30 to 50 million Americans are lactose intolerant.[2] These individuals will develop adverse gastronomical reactions within 20 minutes to two hours after consuming dairy products. Lactase tablets are designed to provide the necessary enzyme allowing for proper digestion, and are a great solution to those who are lactose intolerant.  However, if the lactase supplements still do not relieve discomfort, then you may actually be suffering from protein sensitivity.

Whereas lactose is a carbohydrate, whey and casein are the protein components of milk. The body uses a protease enzyme to break them down for digestion and absorption. Without enough of this enzyme present, then the body will overreact to the presence of the harmless protein, triggering a hyper-response by the immune system. Bloating, nausea, cramping, and pain may occur, which are symptoms similar to those of lactose intolerance. This is why the two conditions are commonly confused for one another.

Millions of people are unable to enjoy dairy products due to digestion complications, but Dairylytic® was created to address both underlying causes of the discomfort: lactose intolerance and protein sensitivity. Dairylytic® is a dual-functioning enzyme formulation with a combination of both lactase and a unique protease enzyme blend. Working together, the enzymes quickly and effectively break down lactose, whey, and casein (proteins) to naturally aid the body in dairy digestion. Rather than individuals completely eliminating a food group from their diet, Dairylytic® can allow them to enjoy foods and beverages that include dairy. For more information, visit us at deerlandenzymes.com today!


[1] http://evolution.berkeley.edu/evolibrary/news/070401_lactose
[2] https://www.fda.gov/forconsumers/consumerupdates/ucm094550.htm

The Great Gluten Break Down: Enzymes for Gluten Digestion

The prevalence of food intolerance is on the rise, with sensitivity to gluten near the top of the list. More than 18 million Americans identify as gluten-sensitive, which is in addition to those suffering from Celiac disease. Gluten is a protein commonly found in wheat, rye, and barley. Gluten sensitivity not only causes digestive discomfort, but can also manifest itself in a variety of ways, including headaches or mental fogginess.  The gliadin portion of the gluten protein is to blame; individuals with sensitivity to gluten are unable to effectively break down and digest this large peptide chain, and undigested gluten proteins trigger the immune system to attack the inner lining of the small intestines. In addition to causing varying levels of digestive discomfort, damaged and inflamed intestines are less efficient at absorbing nutrients, meaning the foods you eat are less nutritious.

Bread, pasta, cookies, cakes, pies—it’s hard to give up gluten. And gluten is not just found in obvious foods like these. Soy sauce, gravy, cream soups, meat substitutes, chocolate and many other foods often contain gluten. For individuals trying to follow a strict gluten-free diet, reading the label is an absolute must.  Those with gluten sensitivity must avoid foods containing gluten—or find a better way to digest it. Fortunately, there is an opportunity for these individuals to facilitate gluten digestion through the use of enzymes that can break down those offending proteins.

Research shows the fastest way to break down gluten proteins is to internally and externally cleave its peptide bonds. Gluten proteins are proline-rich, meaning they do not readily break down during digestion. With this in mind, the scientists at Deerland Enzymes developed an enzyme blend called Glutalytic®, uniquely designed with both endo- and exopeptidases to break down gluten proteins faster and more efficiently than traditional supplements that only contain the exopeptidase DPPIV. Endopeptidases cause quicker protein breakdown because they cut the peptides into smaller pieces, creating more ends for the exopeptidases to digest.

By attacking the gluten protein in two ways, Glutaltyic can degrade gliadin, the major immune-eliciting protein fraction in gluten, down from gram to milligram quantities by the time it reaches the small intestines. Glutaltyic demonstrates a superior ability to quickly and efficiently break down gluten while passing through the stomach and upper duodenum*. In a randomized, double-blind placebo-controlled clinical trial, participants (half of which reported being sensitive to gluten) showed statistically significant improvements in a wide variety of common digestive issues.

Those with severe gluten intolerance must eliminate many foods from their diet, while remaining careful to avoid accidental gluten consumption due to potential cross contamination when dining out or eating at the homes of friends or family.  Glutalytic can serve as a safeguard against accidental gluten consumption, helping to break down those proteins before they begin to wreak havoc on the digestive system.

Glutalytic is not intended to replace a gluten free diet, and is not intended for those with Celiac disease.  Learn more about gluten digestion and Glutalytic at deerlandenzymes.com/glutalytic.

*Under physiological conditions.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. The information contained in this website is intended for educational purposes only. If you are currently taking medications, or have other health-related conditions, consult a physician before adding supplements to your diet.

ProHydrolase® Provides a Better “Whey” for Muscle Building, Says Clinical Study

Whey protein powder – still the “go to” supplement for athletes and routine exercisers — is much better absorbed and utilized when combined with specific protease enzymes, a new study has found.

The most recent double-blind, placebo controlled clinical study of the multi-enzyme compound ProHydrolase® combined with whey protein has shown improved digestion and absorption of amino acids along with reduction of the immunogenic responses associated with whey protein consumption, compared to whey protein alone. The researchers gave 20 volunteers (aged 19 to 35 with normal healthy BMI) whey protein with ProHydrolase® for nine days and whey protein by itself for nine days. At the end of the study, the researchers found that total amino acid concentrations increased significantly (by 55 mg) more after taking the whey protein and ProHydrolase supplement than after just the whey protein-only supplement. In other words – taking whey and ProHydrolase provided 20% more amino acids than whey protein by itself.

ProHydrolase, when consumed with a whey protein supplement, encourages pre-digestion of the protein, allowing for the release of the full content of the essential amino acids for building muscle and improving muscle recovery. This pre-digestion also ensures formation of smaller peptides, reducing the potential for discomfort that is often associated with protein consumption. In the digestive process, whey protein is broken down into peptides, which are themselves broken down into amino acids that become absorbed in the intestinal tract. If the whey isn’t broken down properly, it is simply excreted. Often, large peptides (comprised of more than seven amino acids) may cause digestive discomfort.

The researchers also saw that after taking the combination supplement, levels of CRP (C-reactive protein, a marker of inflammation) decreased significantly – but CRP levels remained mostly static after taking just whey protein by itself. The bioactive peptides created by the hydrolyzed protein curtailed CRP production, indicating a lower level of inflammation in the body.

Here is why this study has mass appeal: whey protein is the top-of-mind powder supplement for muscle-building. But there is an important step that allows for the body to utilize the whey. Whey protein is somewhat cumbersome for the digestive system to efficiently break down and assimilate, a process that requires specific enzymes (proteases). Typical whey proteins are bound together in a peptide complex that needs to be broken down for effective utilization. Ideally, for whey to help promote muscle growth and strength, it should be digested to at least the tetra-peptide level within 90 minutes to be used by the body. Absorption takes place in the small intestines. Larger protein fragments cannot be absorbed and become food for the micro flora in the large intestine which can contribute to unpleasant gas and bloating issues.

This research shows the impact when supplements can be effectively assimilated and thus utilized, thereby meeting label claims. This is crucial, because consumers do not feel their muscles being built and repaired, although they may feel the “afterburn” of a particularly rigorous session. Herein lies the key: it is no longer good enough to just rely upon faith that the protein consumed is going to work. With the addition of the specific protease blend, ProHydrolase, consumers can know for sure that they have a better whey.

A full write-up of the clinical study on ProHydrolase is available by request. Contact Deerland Enzymes for information.

D3 Packaging System Safeguards Supplement Quality

As more Americans turn to probiotics and enzymes to reap their benefits of promoting better digestive and immune health, it’s important that manufacturers provide supplements that remain at the highest level of quality through the time of consumption. Since probiotics are living microorganisms, proper steps must be taken to ensure their vitality from the production facility, through the supply chain, and upon their final destination at target sites within the body. Similarly, enzymes may experience some denaturing if they are not carefully stored and handled.

Just like many supplement ingredients, enzymes and probiotics are known to demonstrate sensitivity to high heat, moisture, and humidity, which makes proper storage and shipping critical. Manufacturers often take steps to monitor and control environmental conditions, but there’s a great opportunity to provide extra protection by considering the actual container or drum that holds the product.

To support customers in their efforts to provide consumers with exceptional quality probiotic and enzyme supplement products, Deerland Enzymes & Probiotics developed the innovative DehydroDryDrum (or D3) system, a drum packaging system aimed at reducing moisture penetration for drum-packed and shipped products. This novel packaging method provides a superior vapor barrier for shipping bulk blends and capsules, compared to standard fiber drums or corrugated boxes.

The D3 system safeguards enzymes and probiotics so that they are well protected when shipped to diverse climates around the world. DehydroDryDrum technology utilizes a fiber exterior, a multi-layered interior of foil and plastic, and plastic lid and gasket for a virtually impenetrable seal. The average moisture gained with standard fiber drums is 6.1%; with the D3 system, that number drops to 2.4%. D3 drums are Food-Sector Packaging Certified, and available in fifteen and thirty gallon sizes.

Shipping conditions can be difficult to control, but Deerland Enzymes’ advanced D3 System helps maintain the reliability and integrity of bulk blends and capsules no matter the climates they encounter at domestic and international destinations.

To learn more about our customized enzyme and probiotic-based formulations and unique shipping technology, visit DeerlandEnzymes.com today!

Systemic Enzymes: A Powerful Catalyst for Optimal Overall Health

Every cell in the human body uses enzymes for building, maintenance and repair. Although the human body naturally produces many enzymes, their production may dwindle as early as age 25. Systemic enzymes are enzymes that not only aid digestion but also support bodily functions in every tissue and organ. These functions include defense against inflammation, fighting infection, modulating the immune system and cleansing the blood of cellular waste and fibrin – a hard, sticky protein formed during clotting of blood. Nearly every process in the human body involves chemical reactions catalyzed by proteins called enzymes.

Systemic enzymes offer various health benefits and may be used as health supplements for specific issues; however, they also serve as excellent prophylactic supplements for general body support. The health benefits (cardiovascular, circulatory and joint health) of systemic enzymes have created a growing niche market. Systemic enzymes promote normal healing and repair in the human body naturally without the side-effects associated with drug products. At Deerland, we offer systemic enzymes, which have a long history of successful use as dietary supplements.

Perhaps the best-known example of systemic enzymes is NSK-SD® nattokinase, which helps maintain a healthy blood pressure and may help sustain cardiovascular health. The claims for nattokinase are corroborated by 25 years of scientific research and testing. Other commonly studied systemic enzymes include bromelain, which degrades fibrin associated with clot formation. The systemic enzyme, serratiopeptidase, has anti-inflammatory properties, and is used to supplement the diet for this benefit.

Systemic enzymes help to speed the resolution of fibrin, clear out cellular waste from the blood to support normal liver function and boost the immune system. Yeast overgrowth results in the release of excessive toxins in the bloodstream, which cause excessive stress on the liver to filter these toxins. Systemic enzymes also help maintain optimal yeast levels for supporting a healthy liver. In combination with a healthy diet, systemic enzymes may help improve overall health. Individuals can use systemic enzymes to ensure continued health and wellness, as enzymes help break down vital nutrients from foods making them more accessible for absorption by the body.

Our society continues to become more hectic and fast-paced every day. The major consequence of this lifestyle is occasional inflammation due to simple over-exertion, bumps and bruises. Deerland Enzymes creates custom enzyme blends for products that target joint health or cardiovascular health, incorporating enzymes such as bromelain, nattokinase and serratiopeptidase. To learn more about the powerful potential of systemic enzymes, contact us at deerlandenzymes.com today!

How to Build Your Enzyme and Probiotic Supplement Formula

The YourBlend Formulator tool is a unique, custom enzyme and probiotic supplement builder tool used to meet our customers’ specific formulation needs. YourBlend allows you to design your own enzyme and probiotic products in the form of bulk powder, bulk capsules or finished bottled product. Choose a basic formula type and target audience to guide you, then select from dozens of enzyme, prebiotic, probiotic, botanical, and vitamin ingredient options to fine-tune your supplement blend. YourBlend will guide you to help ensure your formula has the best possible combination of benefits.

Click below for a detailed look at your customization options, then try your hand at formulating with the YourBlend Formulator tool.

How You Bean?

It’s the little poem we all learned as kids and laughed out loud when we heard it – “beans, beans, the musical fruit, the more you eat, the more you…”, well, you know how it goes. But, it isn’t so funny for the folks who can’t consume beans because of just that embarrassingly audial reason. And for many, it’s more than beans (also called “pulses”); cruciferous vegetables can also engender lower-level gas, but beans are typically the worst offenders.

All these natural foods contain sugars as well as fiber. You likely know that fiber helps fight constipation, keeping bulk moving along and out regularly. But the sugars found in beans and cruciferous vegetables are what cause the issues; they are difficult for the body to digest and absorb.

When a susceptible person eats chili, for example, the beans’ sugars and fibers end up in the colon where they become food for the bacteria that reside there. Funny, it isn’t so much us digesting the sugars from beans – but our colonic colonies chowing down on them. They produce the gas, which is usually hydrogen or carbon dioxide that create methane.

These bean sugars (usually identified by the suffix “-ose”) such as stacchyose, raffinose and verbascose, as well as oligosaccharides, are challenging for the digestive tract where many individuals lack the proper enzymes that help digest them. Lacking the enzymes that further break the sugars down, they pass through to the large intestine unabsorbed. In this lower region, bacteria that thrive here feel like a kid on Christmas morning. They pig out on the sugars and as a result, produce the hydrogen and carbon dioxide en masse, thereby creating the buildup of methane that causes the bloating and the percolating as the methane molecules trample all over themselves running to the exit – some escape, others need to be forced out. The human host, meanwhile, finds a place of solitude until it’s all over.

There’s great news out there if you are the one who hides or has a loved one who must say “No thanks” to any delicious and healthy dish featuring beans and cruciferous vegetables. There are enzyme supplements that can minimize the bloating and gas.

The primary enzyme is alpha-galactosidase (by the way, the suffix “-ase” typically refers to an enzyme.) This enzyme hydrolyzes the raffinose sugars into digestible units that can be absorbed in the small intestines, leaving much less for the bacteria in the colon to consume.

Other enzymes that may also be beneficial for this particular food-digestion issue include invertase, which breaks down the disaccharide sucrose into the monosaccharides glucose and fructose; and lactase, which hydrolyzes lactose into glucose and galactose. These enzymes are transforming one unwieldy sugar molecule into smaller, less problematic, easier-to-digest sugars that are absorbed earlier in the digestive process.

For some individuals, these sugars may also contribute to the production of gas in another way. In a healthy gut environment, beneficial microflora exceed pathogenic (or bad) bacteria. When the ratio begins to swing the other way, when the bad biotics begin to take over, gas and bloating can result, making the person even more susceptible to the creation of flatulence. This condition is known as dysbiosis. Some of those bad bacteria are opportunistic and tend to dominate the population, especially after sickness or antibiotic treatment has wiped out the normal microflora. This is when it might be particularly useful to supplement with probiotics.

Beans don’t have to be the bad guy on the plate, and you or your loved one can enjoy all the goodness they provide by taking enzyme supplements supported by probiotics.

Formulating with Probiotics: Know Your Strains

Health conscious consumers are developing a greater awareness of probiotics and how their bodies rely on the “good” bacteria that live in the gut to execute essential biological processes– ranging from assisting in the manufacture of essential vitamins and minerals, to supporting the metabolism by turning fibers into short-chain fatty acids. Maintaining the intestinal flora is critical to ensuring optimal digestive performance and keeping the body healthy, especially considering that 80% of the body’s immune cells reside in the gut. While consumers receive probiotics from foods like yogurt and kimchi, they are increasingly turning to supplements to give their good gut bacteria an added boost. For supplement product formulators, understanding the types of microorganisms in the gut and their specific functions is important in order to help demanding consumers reach their goals of overall gut health.

The majority of probiotic strains fall into the Lactobacillus and Bifidobacterium genus groups. Both are lactic acid producing bacteria that reside and function in different areas of the gut. Lactobacilli function in the small intestines and Bifidobacteria in the large intestines. In addition to producing lactic acid, Bifidobacteria also produce acetic acid which reduces growth of yeasts and molds.

The different species within these groups perform a variety of different functions and benefits. For example, Lactobacillus acidophilus bacteria help maintain the integrity of intestinal walls, while Lactobacillus fermentum helps neutralize toxic products made during digestion. Lactobacillus rhamnosus is a strain known as the “travel probiotic”, and is found to be effective in reducing traveler’s diarrhea. Bifidobacteria bifidum is especially helpful in properly digesting dairy. Bifidobacteria longum supplements help crowd out bad bacteria, neutralize everyday toxins in the gut, and assist in breaking down carbohydrates without producing excess gas.

Another category of probiotics is spore forming bacteria, such as those in the Bacillus genus. Spore forming bacteria have the ability to generate endospores to protect themselves from harsh conditions until they enter target sites such as the GI tract. Because of their superior resilience, spore forming strains such as Bacillus subtilis-DE111® remain viable under a wide temperature range, eliminating the need for refrigeration. They can survive the stomach’s acidity, crowd out bad bacteria for a better balanced gut flora, and increase immune reaction of intestinal cells.

When formulating a probiotic supplement product, it’s important to know that the potency of probiotics is measured in colony forming units (CFU). CFUs measure the number of live, active organisms present, and are commonly presented in the range of 5-10 billion cells per serving. They are measured at the time of manufacture, and formulated and labeled for the time of consumption. Because not all of the non-spore forming bacteria will remain viable when they arrive at their intended destination in the body, it’s a common practice for manufacturers to formulate with higher doses of probiotic bacteria than the CFU count they list on the label of the product. Including a highly stable spore forming probiotic is a good way to maximize the product’s stability and shelf life.

Consumers are increasingly understanding that caring for the gut, and the good bacteria that reside there, is important to overall health. Different probiotic bacteria have been shown to provide different benefits, so it’s important that a range of probiotics are made available to meet the diverse needs of individuals. Deerland Enzymes and Probiotics is a leading formulator and contract manufacturer of enzyme and probiotic based dietary supplements. For more information about Deerland and the digestive health technologies we offer, visit us online at http://deerlandenzymes.com/about-us-2/

Helping CRN’s OWL Soar

Chaos and confusion frequently stem from something that is unclear, and can be interpreted or handled in multiple ways. When there’s a lack of a discernible, clear trajectory from point of origin to final product, turmoil can reign.

Transparency must be the ultimate goal for the natural products industry to achieve enduring growth, seeded by the trust and loyalty of a public that now considers our products a necessary part of their wellness. It’s a whole different world that links consumers and their self-care regimens than it was in 1994 when DSHEA was passed.

The Online Wellness Library (OWL), a project of the Council for Responsible Nutrition, is a self-regulatory tool that we at Deerland believe will improve transparency and communications between the research community, suppliers, manufacturers and marketers, healthcare practitioners, retailers and consumers. It’s a place where everyone will be “on the same page”, probably for the very first time in our industry’s history.

It’s easy – visit www.supplementowl.org and upload your labels. We believe that through greater participation, transparent information, and continuous updates, the OWL will reassure regulators that we as an industry take consumer safety very seriously as our priority responsibility. Participation in CRN’s OWL is a declaration that ours is an industry of ethics and integrity.

Getting the OWL to soar is not without challenges. A primary challenge right now is getting the information into the system by persuading brands to commit time to upload all product labels. Tier 1 is free and benefits the industry and the consumers. The OWL database provides a list of available products, the associated product labels, their ingredients, and the brands that market them. Consumers use this information for review and decision-making. As confidence grows and the OWL is used more frequently, having your product on the OWL will signify your company’s ethics via transparency, which easily builds trust in your retail/distribution network, consumers – and the regulators who keep an eagle eye on our industry.

As an industry, it is our responsibility to provide regulators with information- and before the OWL, there hasn’t been a central place where regulators can find that information. Another benefit is that through time, interested media and marketers can begin to discern trends, such as where growth areas are occurring.

We at Deerland will work with our customers to provide any pertinent information related to the products we are making to ensure that there is full transparency and trust. A successful OWL ensures the future of the industry and will continue to foster trust among the industry, regulators and the public.