Systemic Enzymes: A Powerful Catalyst for Optimal Overall Health

Every cell in the human body uses enzymes for building, maintenance and repair. Although the human body naturally produces many enzymes, their production may dwindle as early as age 25. Systemic enzymes are enzymes that not only aid digestion but also support bodily functions in every tissue and organ. These functions include defense against inflammation, fighting infection, modulating the immune system and cleansing the blood of cellular waste and fibrin – a hard, sticky protein formed during clotting of blood. Nearly every process in the human body involves chemical reactions catalyzed by proteins called enzymes.

Systemic enzymes offer various health benefits and may be used as health supplements for specific issues; however, they also serve as excellent prophylactic supplements for general body support. The health benefits (cardiovascular, circulatory and joint health) of systemic enzymes have created a growing niche market. Systemic enzymes promote normal healing and repair in the human body naturally without the side-effects associated with drug products. At Deerland, we offer systemic enzymes, which have a long history of successful use as dietary supplements.

Perhaps the best-known example of systemic enzymes is NSK-SD® nattokinase, which helps maintain a healthy blood pressure and may help sustain cardiovascular health. The claims for nattokinase are corroborated by 25 years of scientific research and testing. Other commonly studied systemic enzymes include bromelain, which degrades fibrin associated with clot formation. The systemic enzyme, serratiopeptidase, has anti-inflammatory properties, and is used to supplement the diet for this benefit.

Systemic enzymes help to speed the resolution of fibrin, clear out cellular waste from the blood to support normal liver function and boost the immune system. Yeast overgrowth results in the release of excessive toxins in the bloodstream, which cause excessive stress on the liver to filter these toxins. Systemic enzymes also help maintain optimal yeast levels for supporting a healthy liver. In combination with a healthy diet, systemic enzymes may help improve overall health. Individuals can use systemic enzymes to ensure continued health and wellness, as enzymes help break down vital nutrients from foods making them more accessible for absorption by the body.

Our society continues to become more hectic and fast-paced every day. The major consequence of this lifestyle is occasional inflammation due to simple over-exertion, bumps and bruises. Deerland Enzymes creates custom enzyme blends for products that target joint health or cardiovascular health, incorporating enzymes such as bromelain, nattokinase and serratiopeptidase. To learn more about the powerful potential of systemic enzymes, contact us at today!

How to Build Your Enzyme and Probiotic Supplement Formula

The YourBlend Formulator tool is a unique, custom enzyme and probiotic supplement builder tool used to meet our customers’ specific formulation needs. YourBlend allows you to design your own enzyme and probiotic products in the form of bulk powder, bulk capsules or finished bottled product. Choose a basic formula type and target audience to guide you, then select from dozens of enzyme, prebiotic, probiotic, botanical, and vitamin ingredient options to fine-tune your supplement blend. YourBlend will guide you to help ensure your formula has the best possible combination of benefits.

Click below for a detailed look at your customization options, then try your hand at formulating with the YourBlend Formulator tool.

How You Bean?

It’s the little poem we all learned as kids and laughed out loud when we heard it – “beans, beans, the musical fruit, the more you eat, the more you…”, well, you know how it goes. But, it isn’t so funny for the folks who can’t consume beans because of just that embarrassingly audial reason. And for many, it’s more than beans (also called “pulses”); cruciferous vegetables can also engender lower-level gas, but beans are typically the worst offenders.

All these natural foods contain sugars as well as fiber. You likely know that fiber helps fight constipation, keeping bulk moving along and out regularly. But the sugars found in beans and cruciferous vegetables are what cause the issues; they are difficult for the body to digest and absorb.

When a susceptible person eats chili, for example, the beans’ sugars and fibers end up in the colon where they become food for the bacteria that reside there. Funny, it isn’t so much us digesting the sugars from beans – but our colonic colonies chowing down on them. They produce the gas, which is usually hydrogen or carbon dioxide that create methane.

These bean sugars (usually identified by the suffix “-ose”) such as stacchyose, raffinose and verbascose, as well as oligosaccharides, are challenging for the digestive tract where many individuals lack the proper enzymes that help digest them. Lacking the enzymes that further break the sugars down, they pass through to the large intestine unabsorbed. In this lower region, bacteria that thrive here feel like a kid on Christmas morning. They pig out on the sugars and as a result, produce the hydrogen and carbon dioxide en masse, thereby creating the buildup of methane that causes the bloating and the percolating as the methane molecules trample all over themselves running to the exit – some escape, others need to be forced out. The human host, meanwhile, finds a place of solitude until it’s all over.

There’s great news out there if you are the one who hides or has a loved one who must say “No thanks” to any delicious and healthy dish featuring beans and cruciferous vegetables. There are enzyme supplements that can minimize the bloating and gas.

The primary enzyme is alpha-galactosidase (by the way, the suffix “-ase” typically refers to an enzyme.) This enzyme hydrolyzes the raffinose sugars into digestible units that can be absorbed in the small intestines, leaving much less for the bacteria in the colon to consume.

Other enzymes that may also be beneficial for this particular food-digestion issue include invertase, which breaks down the disaccharide sucrose into the monosaccharides glucose and fructose; and lactase, which hydrolyzes lactose into glucose and galactose. These enzymes are transforming one unwieldy sugar molecule into smaller, less problematic, easier-to-digest sugars that are absorbed earlier in the digestive process.

For some individuals, these sugars may also contribute to the production of gas in another way. In a healthy gut environment, beneficial microflora exceed pathogenic (or bad) bacteria. When the ratio begins to swing the other way, when the bad biotics begin to take over, gas and bloating can result, making the person even more susceptible to the creation of flatulence. This condition is known as dysbiosis. Some of those bad bacteria are opportunistic and tend to dominate the population, especially after sickness or antibiotic treatment has wiped out the normal microflora. This is when it might be particularly useful to supplement with probiotics.

Beans don’t have to be the bad guy on the plate, and you or your loved one can enjoy all the goodness they provide by taking enzyme supplements supported by probiotics.

Formulating with Probiotics: Know Your Strains

Health conscious consumers are developing a greater awareness of probiotics and how their bodies rely on the “good” bacteria that live in the gut to execute essential biological processes– ranging from assisting in the manufacture of essential vitamins and minerals, to supporting the metabolism by turning fibers into short-chain fatty acids. Maintaining the intestinal flora is critical to ensuring optimal digestive performance and keeping the body healthy, especially considering that 80% of the body’s immune cells reside in the gut. While consumers receive probiotics from foods like yogurt and kimchi, they are increasingly turning to supplements to give their good gut bacteria an added boost. For supplement product formulators, understanding the types of microorganisms in the gut and their specific functions is important in order to help demanding consumers reach their goals of overall gut health.

The majority of probiotic strains fall into the Lactobacillus and Bifidobacterium genus groups. Both are lactic acid producing bacteria that reside and function in different areas of the gut. Lactobacilli function in the small intestines and Bifidobacteria in the large intestines. In addition to producing lactic acid, Bifidobacteria also produce acetic acid which reduces growth of yeasts and molds.

The different species within these groups perform a variety of different functions and benefits. For example, Lactobacillus acidophilus bacteria help maintain the integrity of intestinal walls, while Lactobacillus fermentum helps neutralize toxic products made during digestion. Lactobacillus rhamnosus is a strain known as the “travel probiotic”, and is found to be effective in reducing traveler’s diarrhea. Bifidobacteria bifidum is especially helpful in properly digesting dairy. Bifidobacteria longum supplements help crowd out bad bacteria, neutralize everyday toxins in the gut, and assist in breaking down carbohydrates without producing excess gas.

Another category of probiotics is spore forming bacteria, such as those in the Bacillus genus. Spore forming bacteria have the ability to generate endospores to protect themselves from harsh conditions until they enter target sites such as the GI tract. Because of their superior resilience, spore forming strains such as Bacillus subtilis-DE111® remain viable under a wide temperature range, eliminating the need for refrigeration. They can survive the stomach’s acidity, crowd out bad bacteria for a better balanced gut flora, and increase immune reaction of intestinal cells.

When formulating a probiotic supplement product, it’s important to know that the potency of probiotics is measured in colony forming units (CFU). CFUs measure the number of live, active organisms present, and are commonly presented in the range of 5-10 billion cells per serving. They are measured at the time of manufacture, and formulated and labeled for the time of consumption. Because not all of the non-spore forming bacteria will remain viable when they arrive at their intended destination in the body, it’s a common practice for manufacturers to formulate with higher doses of probiotic bacteria than the CFU count they list on the label of the product. Including a highly stable spore forming probiotic is a good way to maximize the product’s stability and shelf life.

Consumers are increasingly understanding that caring for the gut, and the good bacteria that reside there, is important to overall health. Different probiotic bacteria have been shown to provide different benefits, so it’s important that a range of probiotics are made available to meet the diverse needs of individuals. Deerland Enzymes and Probiotics is a leading formulator and contract manufacturer of enzyme and probiotic based dietary supplements. For more information about Deerland and the digestive health technologies we offer, visit us online at

Helping CRN’s OWL Soar

Chaos and confusion frequently stem from something that is unclear, and can be interpreted or handled in multiple ways. When there’s a lack of a discernible, clear trajectory from point of origin to final product, turmoil can reign.

Transparency must be the ultimate goal for the natural products industry to achieve enduring growth, seeded by the trust and loyalty of a public that now considers our products a necessary part of their wellness. It’s a whole different world that links consumers and their self-care regimens than it was in 1994 when DSHEA was passed.

The Online Wellness Library (OWL), a project of the Council for Responsible Nutrition, is a self-regulatory tool that we at Deerland believe will improve transparency and communications between the research community, suppliers, manufacturers and marketers, healthcare practitioners, retailers and consumers. It’s a place where everyone will be “on the same page”, probably for the very first time in our industry’s history.

It’s easy – visit and upload your labels. We believe that through greater participation, transparent information, and continuous updates, the OWL will reassure regulators that we as an industry take consumer safety very seriously as our priority responsibility. Participation in CRN’s OWL is a declaration that ours is an industry of ethics and integrity.

Getting the OWL to soar is not without challenges. A primary challenge right now is getting the information into the system by persuading brands to commit time to upload all product labels. Tier 1 is free and benefits the industry and the consumers. The OWL database provides a list of available products, the associated product labels, their ingredients, and the brands that market them. Consumers use this information for review and decision-making. As confidence grows and the OWL is used more frequently, having your product on the OWL will signify your company’s ethics via transparency, which easily builds trust in your retail/distribution network, consumers – and the regulators who keep an eagle eye on our industry.

As an industry, it is our responsibility to provide regulators with information- and before the OWL, there hasn’t been a central place where regulators can find that information. Another benefit is that through time, interested media and marketers can begin to discern trends, such as where growth areas are occurring.

We at Deerland will work with our customers to provide any pertinent information related to the products we are making to ensure that there is full transparency and trust. A successful OWL ensures the future of the industry and will continue to foster trust among the industry, regulators and the public.

Understanding Probiotic Potency: CFU, Shelf Life and Label Claims

By now, the benefits of probiotics have become well-known among health-conscious consumers. The good bacteria, referred to as probiotics, help to balance out the undesirable bacteria within the digestive tract, promoting overall gut health. While the advantages of probiotics are clear, there remains some confusion about how probiotics are measured for efficacy, and how they should be properly handled so that individuals get the most from their supplements.

Probiotics are defined as “living microorganisms which when administered in sufficient quantities will bring a health benefit to the host”. Because these are living organisms, special care must be taken so that they remain viable until consumption. These beneficial bacteria face a wide range of challenges that may decrease their numbers before consumption, thus reducing the beneficial effects of supplement product. During the supply-to-shelf chain alone—light, heat, oxygen, and moisture all pose threats to vitality, so it is inevitable that a portion of the bacteria may expire somewhere before consumption. Even after consumption, many probiotics can be destroyed by stomach acid before reaching their target sites in the intestines, further reducing their effects. When formulating a product, careful selection of organisms with the most desirable characteristics is required to deliver the optimal probiotic supplement.

The potency of probiotics is measured in colony forming units (CFU). CFUs are determined by allowing the organism to grow on appropriate media under controlled conditions, and then counting the number of colonies present. Typical counts for a supplement product may be in the range of 5-10 billion CFUs per serving. Because not all the bacteria will remain viable when they arrive at their intended destination in the gut, manufactures tend to begin with higher doses of probiotic bacteria than is required to provide benefits. Plus, if an expiration date is specified on the label, the CFU count must reflect the number remaining at the end of that expiration date.

Understanding labeling and proper storage requirements of probiotics will help ensure a quality supplement product. Refrigeration requirements vary amongst probiotic organisms, but generally cooler temperatures and dryer conditions will yield a longer shelf life. Spore-forming strains, such as Bacillus genus, have a more stable shelf life, and are better suited to withstand environmental factors, allowing for greater potency when consumed.

Probiotics are critical to supporting gut health and overall wellbeing, but these living organisms may face a host of challenges to their viability that begin the minute they are formed, and do not end until digestion. Knowing how to maximize stability through careful formulation and proper storage will help manufacturers ensure that their consumers achieve the greatest benefits from their probiotic supplement. Deerland Enzymes and Probiotics, a leading specialty formulator and contract manufacturer of enzyme and probiotic-based dietary supplements, provides high-quality formulas, carefully manufactured and handled for maximum stability and shelf life. For more information about us and our range of wellness products, visit us online at

Digestive Health Supplements Yield a Measurable Difference

The simple purpose of a dietary supplement is to improve the health of the consumer, ultimately making an appreciable difference in the quality of people’s lives. When consumers can feel the positive results of taking a supplement, they are highly likely to continue purchasing that product. And with 37% of U.S. consumers reporting digestive issues, there’s a lot of opportunity for supplement companies to focus their efforts on providing quality products aimed at gut health.

Many health problems can be traced to the gut.  Our diets are filled with convenience foods that often contain preservatives, artificial sweeteners, and sugars that negatively affect the microbiome (bacterial population) of the gut by encouraging the growth of Candida and undesirable strains of bacteria. It is important to take extra steps to maintain a healthy balance of bacteria in the gut, and the right digestive health supplement can help create just that.

The microbiota, often referred to as the microbiome, is the ecological community of microorganisms that make up about half the body’s cells. The typical human microbiome consists of about 80% healthy and 20% pathogenic microorganisms, but all too many people are imbalanced, with far too many bad bacteria taking up residence in the gut.

It’s hard to overestimate the importance of a healthy gut. A healthy level of good bacteria in the gut aids in digestion and produces a variety of vitamins and nutrients the body needs. Acute symptoms like acid reflux, stomach upset, intestinal cramps, and gas are all warning signs that the digestive tract isn’t functioning properly, and may be imbalanced. A healthy gut not only alleviates digestive discomfort—it also lifts both mood and brain fog, sharpening thinking and increasing feelings of happiness and well-being. Indeed, anxiety, nervousness, and stress are often caused by an unhealthy digestive system. As if that weren’t enough, poor gut health causes negative effects on the immune system, leading to allergies and inflammation.

An improperly balanced microbiome can create a vicious cycle. Too many bad bacteria in the gut results in poor nutrition, reduced energy and ultimately a compromised immune system. Bad bacteria and Candida thrive in these conditions, and continue to grow in the gut. Repopulating the gut with good bacteria that will crowd out the bad bacteria is key, and a digestive health supplement that incorporates enzymes, probiotics and/or prebiotics is the most effective, efficient way to break this cycle and get on the path to overall wellness. Digestive enzymes can help to optimize the digestion process for the complete release and absorption of food nutrients.  Probiotics rebuild the proper microbiome balance, and prebiotics help these good bacteria thrive and take up residence in the gut for sustained benefits.

The gut microbiome is one of the most exciting areas of science today; Deerland Enzymes & Probiotics takes pride in the science-supported formulations we develop for digestive health. Although we specialize in customized formulations, we have also developed an exclusive line of university-studied products to offer to our customers, which can be used as-is, or the basis for a custom formulation.  Visit us and learn more at!


The Position of Enzymes in Sports Nutrition

Everyone knows protein is a macronutrient that is essential to maintaining a healthy diet and lifestyle. For active individuals, whether they’re everyday fitness enthusiasts or serious athletes, the need for protein is even greater as it plays a key role in muscle recovery. In order to meet growing consumer demand for protein, many food products and supplements are boosting their offerings with more of the macronutrient. But not everyone understands the important role enzymes play in protein digestion. Without them, they may not be receiving the full nutritional benefits of protein consumption.

Whey is a protein found in milk and is the most popular protein on the market. It’s the supplement of choice among body builders, athletes, and casual health conscious individuals seeking an alternative to carbohydrate-rich or fatty foods. The biggest appeal of whey protein is its amino acid profile; whey contains the highest percentage of essential amino acids, 25% of which are the BCAAs leucine, isoleucine, and valine, the most important for muscle building and tissue repair.

However, for whey protein to be effective, it must be broken down into smaller particles within 90 minutes of consumption through a process known as hydrolysis. It takes approximately 90 minutes for the whey protein to pass from the stomach through the small intestine for digestion, absorption, and assemblage into a bio-usable form for muscle synthesis. Protein that goes undigested is excreted from the body, rendering it useless to consumers hoping to improve muscle recovery. In addition, the body’s failure to break down whey protein into small particles results in the formation of large peptides. These large molecules are the cause of the discomforts that many people experience after consuming a large amount of whey protein, and can include bloating, nausea and cramping. Some people may chalk these discomforts up to lactose intolerance, since whey is a dairy protein.  However, lactose is not present in whey isolates.

With greater consumption of protein comes the need for more enzyme supplements to aid in absorption. ProHydrolase® uses a proprietary blend of enzymes to help the body better digest and absorb high quantities of protein. Backed by two human clinical studies, ProHydrolase has been shown to break down protein into smaller peptides to allow for more effective absorption, and to reduce the potential for digestive discomfort. The studies demonstrate that when consumed along with whey protein, the nutritional supplement increases amino acids in the blood by 20% (compared to whey protein alone), improving muscle synthesis. It is also effective when used with soy, casein, hemp and pea proteins.

ProHydrolase has been tested with some of the most popular protein supplements on the market, and was found to effectively break them down by 99%, degrade 99% of the peptides responsible for stomach discomfort, and is two to three times faster at protein hydrolysis than other protein degrading sports formulas. Active individuals looking to enhance their performance or or accelerate their recovery should turn to ProHydrolase® to get the most out of their protein consumption.

Prebiotics Clear the Way for Probiotics to Thrive

At this point, mostly everyone has heard about probiotics – those ‘friendly’ living microorganisms like yeasts and bacteria that inhabit our intestines, promoting proper and regular digestion. They appear in popular yogurts, teas, kombucha, and supplements. Probiotics support the immune system and can aid those suffering from common GI discomforts such as bloating, gas, or diarrhea. But while probiotics have gotten a lot of attention over the last decade, less has been said about their equally important partner, prebiotics.

Prebiotics are non-living, non-digestible ingredients that fuel the good probiotic microorganisms living inside us, helping them flourish. Prebiotics are generally fibers or starches commonly found in legumes, whole wheat foods, onions, cabbages, asparagus, and oatmeal. When used as an ingredient in supplement products, they typically require large doses to be effective (up to 20-40 grams!), and carry the common side effect of flatulence as a result of large molecules of fiber. Still, a balanced combination of prebiotics and probiotics can help individuals maintain overall wellbeing.

Recognizing the importance of prebiotics to a balanced microflora in the gut, researchers at Deerland have developed an innovative prebiotic that supports the growth of healthy bacteria in the gut through a mechanism that is neither fiber nor starch-based. It’s called PreforPro®. Unlike other prebiotics, PreforPro does not require large doses to be effective (only 15mg), and does not cause gas. It functions in both the small and large intestines, and is not affected by varying gut environments. It works with a broad spectrum of probiotic species to give the digestive system an effective boost.

The good probiotic microorganisms we rely on compete with harmful bacteria in our gut that can steal essential nutrients our bodies would normally absorb. This unbalanced bacterial flora condition can result in a variety of gastrointestinal issues, including abdominal pain, indigestion, bloating, food allergies, and malnutrition. PreforPro supports the growth of the good bacteria so they can displace the bad and allow your body to thrive. Within hours of consumption, PreforPro goes to work on the undesirable bacteria in the gut by destabilizing the bacterial cell wall, releasing nutrients into the environment which can then be consumed by the good bacteria within the GI tract. Much like a gardener would prepare the soil before planting seeds to ensure they have the proper conditions to grow, PreforPro prepares the gut to ensure healthy bacteria have room to flourish. Lab testing has shown PreforPro promotes the growth of beneficial Lactobacillus, Bifidobacterium and Bacillus subtilis bacterial strains when competing with undesirable E. coli bacteria.

PreforPro is a truly novel prebiotic ingredient that gives the probiotics living inside you a fighting chance. To learn more about PreforPro or other products, visit

The Journey of a Probiotic: From Raw Material to Finished Product

Proper handling is paramount in the manufacturing of probiotic supplement products. At Deerland Probiotics, the journey of a probiotic from raw material to finished product begins as soon as the material arrives at the warehouse of the manufacturing facility, and continues until refrigerated trucks deliver the finished QA and QC-approved product to the customer. This journey encompasses more than 30 steps, as the probiotic moves from its arrival as a premium raw material through several rigorous phases of quality assurance and production, including testing, staging, weighing, blending, encapsulating and bottling. Every step in the process is vitally important in ensuring a safe and efficacious finished product.

Click the image below for a more detailed look at the journey.